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Degradation of aromatic compounds

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
Naphthyl-2-hydroxymethyl-succinyl_CoA <=> Naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ 1.1
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benzoate + NADPH + H+ + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NADP+ 1.14.12.10 benzoate 1,2-dioxygenase
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benzaldehyde + H2O + NAD+ <=> aromatic_carboxylate + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
1.2.1.48 long-chain-aldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.67 vanillin dehydrogenase
1.2.1.69 fluoroacetaldehyde dehydrogenase
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(2E,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate 4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase
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propionaldehyde + CoA + NAD+ <=> propionyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)
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phenanthrene + NADH + H+ + O2 <=> (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD+ 1.13.11
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cis-Chlorobenzene_dihydrodiol + NAD+ <=> tetrachlorocatechol + NADH + H+ 1.3.1
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2-carboxymethyl-3-hydroxyphenylpropionyl-CoA + NAD+ <=> Benzoylsuccinyl-CoA + NADH + H+ 1.1.1
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
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–
benzoyl-CoA + reduced_acceptor <=> cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor 1.3
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cis-1,2-Dihydroxy-3,6-dichlorocyclohexa-3,5-diene + NAD+ <=> 3,6-dichlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
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1-hydroxy-2-naphthoate + NADH + O2 + H+ <=> 1,2-dihydroxynaphthalene + NAD+ + H2O + CO2 1.14.13.1 salicylate 1-monooxygenase
1.14.13.135 1-hydroxy-2-naphthoate hydroxylase
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2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> H+ + 3-carboxy-cis,cis-muconate 5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase
5.5.1.5 carboxy-cis,cis-muconate cyclase
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3-(2,3-dihydroxyphenyl)propanoate + O2 <=> H+ + (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate 1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
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catechol + O2 <=> H+ + cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.3 protocatechuate 3,4-dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase
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2-Methylbenzyl_alcohol + NAD+ <=> 2-Methylbenzaldehyde + NADH 1.1.1.90 aryl-alcohol dehydrogenase
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Cyclohexanol + NAD+ <=> cyclohexanone + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.112 indanol dehydrogenase
1.1.1.163 cyclopentanol dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.243 carveol dehydrogenase
1.1.1.245 cyclohexanol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
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6-Oxo-2-hydroxy-7-(4''-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate + H2O <=> 2-(4''-Chlorophenyl)-3,3-dichloropropenoate + (2Z)-3-chloro-2-hydroxypenta-2,4-dienoic_acid 3.7.1
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2-Hydroxy-2H-benzo[h]chromene-2-carboxylate <=> cis-4-(1''-Hydroxynaphth-2''-yl)-2-oxobut-3-enoate 5.1.2
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2-Oxo-5-methyl-cis-muconate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienoate + CO2 4.1.1.77 2-oxo-3-hexenedioate decarboxylase
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H+ + 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> CO2 + 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid 4.1.1.44 4-carboxymuconolactone decarboxylase
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6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ <=> H+ + 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH 1.1.1.368 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
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5-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ <=> 4-Fluorocatechol + NADH + CO2 + H+ 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
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4,6-Dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ <=> 4,6-Dichloro-3-methylcatechol + NADH + H+ 1.3.1
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4-Methylbenzoate + O2 + NADH + H+ <=> cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD+ 1.14.12
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2-Hydroxy-3-methylbenzalpyruvate + H2O <=> 2-hydroxy-3-methylbenzaldehyde + pyruvate 4.2.1
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3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> H+ + 4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid 1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
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2-carboxymethyl-3-hydroxyphenylpropionyl-CoA <=> (E)-2-benzylidenesuccinyl-CoA + H2O 4.2.1
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4-methylcatechol + O2 <=> 3-methyl-cis,cis-muconate + H+ 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.3 protocatechuate 3,4-dioxygenase
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4-Chlorophenol + O2 + NADPH + H+ <=> 4-Chlorocatechol + H2O + NADP+ 1.14.13.20 2,4-dichlorophenol 6-monooxygenase
1.14.13.7 phenol 2-monooxygenase (NADPH)
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2,4-Dichlorophenoxyacetic_acid + 2-oxoglutarate + O2 <=> 2,4-Dichlorophenol + glyoxylate + succinate + CO2 1.14.11
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4-methylbenzaldehyde + NADP+ + H2O <=> 4-Methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
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5-oxopent-3-ene-1,2,5-tricarboxylate + H+ <=> 2-hydroxyhepta-2,4-dienedioate + CO2 4.1.1.68 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
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2,6-dichlorophenol + O2 + NADH + H+ <=> 2,6-dichlorohydroquinone + NAD+ + H2O 1.14.13
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2-hydroxymuconate-6-semialdehyde + H2O + NAD+ <=> 2-hydroxy-2,4-hexadienedioate + NADH + H+ 1.2.1.32 aminomuconate-semialdehyde dehydrogenase
1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase
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2-hydroxycyclohexane-1-carbonyl-CoA + NAD+ <=> H+ + 2-ketocyclohexane-1-carboxyl-CoA + NADH 1.1.1
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(1R,2S,4R)-neo-dihydrocarveol + NAD+ <=> (4R)-dihydrocarvone + NADH + H+ 1.1.1.296 dihydrocarveol dehydrogenase
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4-Fluorocyclohexadiene-cis,cis-1,2-diol + NAD+ <=> 4-Fluorocatechol + NADH + H+ 1.3.1
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2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde + NAD+ + H2O <=> (2E,4Z)-2-hydroxy-5-methylhexa-2,4-diendioate + NADH + H+ 1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase
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1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ <=> 3-methylcatechol + CO2 + NADH + H+ 1.3.1
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H+ + o-Cresol + NADH + O2 <=> 3-methylcatechol + NAD+ + H2O 1.14.13.236 toluene 4-monooxygenase
1.14.13.243 toluene 2-monooxygenase
1.14.13.44 2-hydroxybiphenyl 3-monooxygenase
1.14.13.7 phenol 2-monooxygenase (NADPH)
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2-Naphtylmethylsuccinic_acid + succinyl-CoA <=> Naphthyl-2-methyl-succinyl-CoA + succinate 2.8.3
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4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid + H2O <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+ 3.7.1.17 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
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1,2,3,4-tetrachlorobenzene + O2 + NADH + H+ <=> cis-Chlorobenzene_dihydrodiol + NAD+ 1.14.12
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propionaldehyde + pyruvate <=> 4-hydroxy-2-oxohexanoate 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase
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4-hydroxyphenylacetate + NADH + O2 <=> 3,4-Dihydroxyphenylacetate + NAD+ + H2O 1.14.12.9 4-chlorophenylacetate 3,4-dioxygenase
1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase
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(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + 2-hydroxy-2,4-pentadienoate 3.7.1.13 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase
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ATP + adipate + CoA <=> AMP + diphosphate + adipyl-CoA 6.2.1
6.2.1.14 6-carboxyhexanoate---CoA ligase
6.2.1.23 dicarboxylate---CoA ligase
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H2O + 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid <=> H+ + 3-oxoadipate 3.1.1.24 3-oxoadipate enol-lactonase
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O2 + 2,3-Dihydroxybiphenyl <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ 1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
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2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> benzoate + 2-oxopent-4-enoate 3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
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(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> Salicylaldehyde + pyruvate 4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
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2-Methylbenzaldehyde + NADP+ + H2O <=> 2-Methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
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NAD+ + (+)-cis-3,4-dihydrophenanthrene-3,4-diol <=> H+ + NADH + 3,4-Dihydroxyphenanthrene 1.3.1.49 cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase
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(3R)-3-isopropenyl-6-oxoheptanoate + CoA + ATP <=> (3R)-3-Isopropenyl-6-oxoheptanoyl-CoA + H2O + AMP + diphosphate 6.2.1
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cis-1,2-Dihydroxy-1,2-dihydro-8-methylnaphthalene + NAD+ <=> 1,2-Dihydroxy-8-methylnaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
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(4S)-(+)-muconolactone <=> H+ + cis,cis-muconate 5.5.1.1 muconate cycloisomerase
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cis-3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorocyclohexa-3,5-diene-1,2-diol + NAD+ <=> 1,1-Dichloro-2-(dihydroxy-4''-chlorophenyl)-2-(4''-chlorophenyl)ethylene + NADH + H+ 1.3.1
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3-methylsalicylate + NADH + O2 <=> 3-methylcatechol + CO2 + NAD+ + H2O 1.14.13.1 salicylate 1-monooxygenase
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Toluene + O2 + NADH + H+ <=> p-Cresol + H2O + NAD+ 1.14.13.236 toluene 4-monooxygenase
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O2 + 3,4-dihydroxybenzoate <=> H+ + 3-carboxy-cis,cis-muconate 1.13.11.3 protocatechuate 3,4-dioxygenase
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3-hydroxycinnamic_acid + O2 + NADH + H+ <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+ 1.14.13.127 3-(3-hydroxyphenyl)propanoate hydroxylase
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2-ketocyclohexane-1-carboxyl-CoA + H2O <=> H+ + pimeloyl-CoA 3.1.2
3.7.1
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2-hydro-1,2-dihydroxybenzoate + NAD+ <=> catechol + CO2 + NADH 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
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O2 + 3,4-Dihydroxyphenylacetate <=> H+ + 5-carboxymethyl-2-hydroxymuconate_semialdehyde 1.13.11.15 3,4-dihydroxyphenylacetate 2,3-dioxygenase
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4-methylbenzyl_alcohol + NAD+ <=> H+ + 4-methylbenzaldehyde + NADH 1.1.1.21 aldose reductase
1.1.1.90 aryl-alcohol dehydrogenase
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2-Fluorobenzoate + NADH + H+ + O2 <=> 6-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
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benzoate <=> 3-hydroxybenzoate not assigned
 –
NAD+ + (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol <=> H+ + NADH + 3-methylcatechol 1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
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2-Hydroxy-6-oxoocta-2,4,7-trienoate + H2O <=> 2-hydroxy-2,4-pentadienoate + Acrylate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase
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(4R)-dihydrocarvone + NADPH + H+ + O2 <=> (4R)-4-isopropenyl-7-methyl-2-oxo-oxepanone + NADP+ + H2O 1.14.13.105 monocyclic monoterpene ketone monooxygenase
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p-coumaric_acid <=> caffeic_acid 1.14.13
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cyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxycyclohexane-1-carbonyl-CoA 4.2.1
4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
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biphenyl + O2 + NADH + H+ <=> cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+ 1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
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(2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> 2-hydroxy-2,4-pentadienoate + succinate 3.7.1.14 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
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4-hydroxy-2-oxopentanoate <=> pyruvate + acetaldehyde 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase
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(S)-1-phenylethanol + NAD+ <=> H+ + acetophenone + NADH 1.1.1.1 alcohol dehydrogenase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.311 (S)-1-phenylethanol dehydrogenase
1.1.1.B3
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xylene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 3-methylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase
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1-hydroxy-2-naphthaldehyde + NAD+ + H2O <=> 1-hydroxy-2-naphthoate + NADH + H+ 1.2.1
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(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 <=> (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H+ 1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
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1-methylnaphthalene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-8-methylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
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phenol + O2 + NADH + H+ <=> catechol + H2O + NAD+ 1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)
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3-hydroxybenzoate + O2 + NADPH + H+ <=> 3,4-dihydroxybenzoate + H2O + NADP+ 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.23 3-hydroxybenzoate 4-monooxygenase
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Benzoylsuccinyl-CoA + CoA <=> benzoyl-CoA + succinyl-CoA 2.3.1
2.3.1.M17
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(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ <=> 1,2-dihydroxynaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
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6-hydroxyhexanoate + NAD+ <=> H+ + 6-oxohexanoate + NADH 1.1.1.258 6-hydroxyhexanoate dehydrogenase
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3-Phenylpropionic_acid <=> 3-(3-Hydroxyphenyl)propanoic_acid not assigned
 –
cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+ <=> 3-chlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
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4''-chloro-2,3-dihydroxybiphenyl + O2 <=> 2-hydroxy-6-oxo-6-(4''-chlorophenyl)-hexa-2,4-dienoate + H2O 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
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cis-benzene_dihydrodiol + NAD+ <=> catechol + NADH + H+ 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
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1,2-dihydroxynaphthalene + O2 <=> H+ + 2-hydroxy-2H-chromene-2-carboxylate 1.13.11.56 1,2-dihydroxynaphthalene dioxygenase
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2-Chlorobenzoate + O2 + NADH + H+ <=> catechol + Cl- + CO2 + NAD+ 1.14.12.13 2-halobenzoate 1,2-dioxygenase
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2-Hydroxy-6-oxo-6-(4''-chlorophenyl)-hexa-2,4-dienoate + H2O <=> 4-Chlorobenzoate + 2-hydroxy-2,4-pentadienoate 3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
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carbazole + O2 + NADPH + H+ <=> 2''-aminobiphenyl-2,3-diol + NADP+ 1.14.12.22 carbazole 1,9a-dioxygenase
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6-hydroxyhexanoate + NADP+ <=> 6-oxohexanoate + NADPH + H+ 1.1.1.2 alcohol dehydrogenase (NADP+)
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3-Hydroxybenzyl_alcohol + NADP+ <=> 3-Hydroxybenzaldehyde + NADPH + H+ 1.1.1.184 carbonyl reductase (NADPH)
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
1.1.1.97 3-hydroxybenzyl-alcohol dehydrogenase
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2-hydroxy-2,4-hexadienedioate <=> 4-oxalocrotonate 5.3.2.6 2-hydroxymuconate tautomerase
5.3.2.M1
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chlorobenzene + O2 + NADH + H+ <=> cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+ 1.14.12.26 chlorobenzene dioxygenase
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2-hydroxy-2,4-pentadienoate + acetate <=> 2-hydroxy-6-oxohepta-2,4-dienoate + H2O 3.7.1.25 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
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2-oxohept-3-enedioate <=> 2-hydroxyhepta-2,4-dienedioate 5.3.2.6 2-hydroxymuconate tautomerase
5.3.3
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dibenzo-p-dioxin + NADH + O2 <=> 2,2'',3-trihydroxybiphenyl_ether + NAD+ 1.14.12
1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
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H+ + 4-toluenesulfonate + O2 + NADH <=> 4-(hydroxymethyl)benzenesulfonate + NAD+ + H2O 1.14.13
1.14.99
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4-nitrophenyl + O2 + NADH <=> catechol + nitrite + NAD+ 1.14.12.23 nitroarene dioxygenase
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cyclohexanone + NADPH + H+ + O2 <=> epsilon-caprolactone + NADP+ + H2O 1.14.13.16 cyclopentanone monooxygenase
1.14.13.22 cyclohexanone monooxygenase
1.14.13.92 phenylacetone monooxygenase
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3-methylbenzyl_alcohol + NAD+ <=> H+ + 3-methylbenzaldehyde + NADH 1.1.1.21 aldose reductase
1.1.1.90 aryl-alcohol dehydrogenase
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H+ + Phthalate + O2 + NADH <=> Phthalate_3,4-cis-dihydrodiol + NAD+ 1.14.12
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3,4,6-Trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ <=> 3,4,6-trichlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
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3-methylcatechol + O2 <=> 2-hydroxy-6-oxohepta-2,4-dienoate + H+ 1.13.11
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
1.13.11.2 catechol 2,3-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
1.13.11.56 1,2-dihydroxynaphthalene dioxygenase
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4-chlorobiphenyl + O2 + NADH + H+ <=> cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NAD+ 1.14.12.18 biphenyl 2,3-dioxygenase
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4-fluoro-2-hydro-1,2-dihydroxybenzoate + NAD+ <=> 4-Fluorocatechol + NADH + CO2 + H+ 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
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ethylbenzene + H2O + acceptor <=> (S)-1-phenylethanol + reduced_acceptor 1.17.99.2 ethylbenzene hydroxylase
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cis-Chlorobenzene_dihydrodiol + NADP+ <=> tetrachlorocatechol + NADPH + H+ 1.3.1
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H+ + Naphthalene + O2 + NADH <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
1.14.12.23 nitroarene dioxygenase
1.14.12.24 2,4-dinitrotoluene dioxygenase
–
–
–
–
3-Hydroxybenzaldehyde + NADP+ + H2O <=> 3-hydroxybenzoate + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
–
–
Toluene + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> benzyl_alcohol + oxidized_ferredoxin + H2O 1.14.13
1.14.15.26 toluene methyl-monooxygenase
–
–
3-Phenylpropionic_acid + NADH + O2 + H+ <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ 1.14.12.19 3-phenylpropanoate dioxygenase
–
benzoate + NADH + H+ + O2 <=> 2-hydro-1,2-dihydroxybenzoate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
H+ + Toluene + O2 + NADH <=> o-Cresol + H2O + NAD+ 1.14.13.243 toluene 2-monooxygenase
–
Phthalate + O2 + NADH + H+ <=> cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ 1.14.12.7 phthalate 4,5-dioxygenase
–
catechol + O2 <=> 2-hydroxymuconate-6-semialdehyde + H+ 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
1.13.11.2 catechol 2,3-dioxygenase
1.13.11.36 chloridazon-catechol dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
–
–
–
–
–
–
4-formylbenzenesulfonate + NAD+ + H2O <=> H+ + 4-Sulfobenzoate + NADH 1.2.1.62 4-formylbenzenesulfonate dehydrogenase
–
2-methylnaphthalene + O2 + NADH + H+ <=> 2-naphthalenemethanol + NAD+ + H2O 1.14.13
–
3-Fluorobenzoate + NADH + H+ + O2 <=> 5-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
3-oxo-3-phenylpropionic_acid + CoA + ATP <=> benzoylpropionyl-CoA + AMP + diphosphate 6.2.1
–
4-oxalocrotonate <=> 2-oxopent-4-enoate + CO2 4.1.1.77 2-oxo-3-hexenedioate decarboxylase
–
Toluene + O2 + NADPH + H+ <=> m-cresol + NADP+ + H2O 1.14.13
–
4-Methylbenzoate + O2 + NADPH + H+ <=> cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ 1.14.12
–
Perillyl-CoA + H2O <=> 2-Hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA 4.2.1
–
benzoate + reduced_flavodoxin + O2 <=> 4-hydroxybenzoate + flavin + H2O 1.14.14.1 unspecific monooxygenase
1.14.14.92 benzoate 4-monooxygenase
–
–
5-carboxymethyl-2-hydroxymuconate_semialdehyde + H2O + NADP+ <=> 5-Carboxymethyl-2-hydroxymuconate + NADPH 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
–
–
6-hydroxycyclohex-1-ene-1-carbonyl-CoA <=> cyclohexa-1,5-diene-1-carbonyl-CoA + H2O 4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
–
cyclohex-1-ene-1-carbonyl-CoA + flavin <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced_flavodoxin 1.3.8.10 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase
–
4-Isopropylbenzyl_alcohol + NAD+ <=> cuminaldehyde + NADH + H+ 1.1.1.90 aryl-alcohol dehydrogenase
1.1.1.M33
–
–
benzoyl-CoA + oxidized_ferredoxin + H2O <=> 4-hydroxybenzoyl-CoA + reduced_ferredoxin 1.1.7.1 4-hydroxybenzoyl-CoA reductase
–
1-hydroxy-2-naphthaldehyde + pyruvate <=> (3E)-4-(1-hydroxynaphthalen-2-yl)-2-oxobut-3-enoate + H2O 4.1.2
4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
–
–
2-xylene + O2 + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ <=> 2-Methylbenzyl_alcohol + 2 oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase
–
2-Hydroxy-8-methylchromene-2-carboxylate <=> 2-Hydroxy-3-methylbenzalpyruvate 5.3.99
–
4-cymene + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 4-Isopropylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.25 p-cymene methyl-monooxygenase
–
Benzene + NADH + O2 <=> phenol + NAD+ + H2O 1.14.13.236 toluene 4-monooxygenase
1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.25 methane monooxygenase (soluble)
–
–
–
cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ <=> H+ + 2,3-Dihydroxy-p-cumate + NADH 1.3.1.58 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
–
Naphthyl-2-oxomethyl-succinyl-CoA + CoA <=> 2-Naphthoyl-CoA + succinyl-CoA 2.3.1
–
NADP+ + cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate <=> CO2 + NADPH + 4-methylcatechol 1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
–
carbazole + O2 + NADH + H+ <=> 2''-aminobiphenyl-2,3-diol + NAD+ 1.14.12.22 carbazole 1,9a-dioxygenase
–
H+ + dibenzofuran + NADH + O2 <=> 2,2',3-Trihydroxybiphenyl + NAD+ 1.14.12
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
2-methylnaphthalene + fumarate <=> 2-Naphtylmethylsuccinic_acid 4.1.99
–
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O <=> Isobutyrate + 2-hydroxy-2,4-pentadienoate 3.7.1
–
2,6-dibromophenol <=> 2,6-dibromo-p-hydroquinone not assigned
 –
4-methyl-3-oxoadipate_enol-lactone + H2O <=> 4-methyl-3-oxoadipate + H+ 3.1.1
3.1.1.24 3-oxoadipate enol-lactonase
–
–
6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> H+ + 3-hydroxypimeloyl-CoA 3.7.1.21 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase
–
(4R)-4-isopropenyl-7-methyl-2-oxo-oxepanone + H2O <=> (3R)-6-Hydroxy-3-isopropenyl-heptanoate 3.1.1.83 monoterpene epsilon-lactone hydrolase
–
4-hydroxybenzoate + NADH + O2 + H+ <=> 3,4-dihydroxybenzoate + NAD+ + H2O 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
1.14.99.15 4-methoxybenzoate monooxygenase (O-demethylating)
–
–
–
2-Methylbenzoate + O2 + NADH + H+ <=> 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ 1.14.12
–
terephthalate + O2 + NADH + H+ <=> (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ 1.14.12.15 terephthalate 1,2-dioxygenase
–
6-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate <=> 3-fluorocatechol 1.3.1
–
2''-aminobiphenyl-2,3-diol + O2 <=> H+ + (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate 1.13.11
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
–
–
O2 + reduced_acceptor + 4-Methoxybenzoate <=> H2O + acceptor + 4-hydroxybenzoate + formaldehyde 1.14.99.15 4-methoxybenzoate monooxygenase (O-demethylating)
–
epsilon-caprolactone + H2O <=> H+ + 6-hydroxyhexanoate 3.1.1
3.1.1.17 gluconolactonase
3.1.1.83 monoterpene epsilon-lactone hydrolase
–
–
–
(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O <=> 2-hydroxy-2,4-pentadienoate + fumarate 3.7.1.14 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
–
Naphthyl-2-methyl-succinyl-CoA <=> Naphthyl-2-methylene-succinyl-CoA + 2 H+ 1.3.99
–
trans-cinnamate <=> 3-hydroxycinnamic_acid not assigned
 –
Styrene-cis-2,3-dihydrodiol + NAD+ <=> 3-vinylcatechol + NADH + H+ 1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
–
2,2'',3-Trihydroxybiphenyl + O2 <=> 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate 1.13.11
–
(2E,4Z)-2-hydroxy-5-methylhexa-2,4-diendioate <=> 2-Oxo-5-methyl-cis-muconate 5.3.2.6 2-hydroxymuconate tautomerase
–
H+ + 3-(3-hydroxyphenyl)propanoate + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+ 1.14.13.127 3-(3-hydroxyphenyl)propanoate hydroxylase
–
1,2-Dihydroxy-8-methylnaphthalene + O2 <=> 2-Hydroxy-8-methylchromene-2-carboxylate 1.13
–
2,4-Dichlorophenol + O2 + NADPH + H+ <=> 3,5-dichlorocatechol + H2O + NADP+ 1.14.13.20 2,4-dichlorophenol 6-monooxygenase
–
4-Chlorophenoxyacetate + 2-oxoglutarate + O2 <=> 4-Chlorophenol + glyoxylate + succinate + CO2 1.14.11
–
5-Carboxymethyl-2-hydroxymuconate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate 5.3.3.10 5-carboxymethyl-2-hydroxymuconate Delta-isomerase
–
2-naphthaldehyde + NAD+ + H2O <=> 2-naphthoic_acid + NADH 1.2.1
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
–
–
–
–
–
1,2,4-trichlorobenzene + O2 + NADH + H+ <=> 3,4,6-Trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ 1.14.12.26 chlorobenzene dioxygenase
–
H+ + cumic_acid + NADH + O2 <=> cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ 1.14.12.25 p-cumate 2,3-dioxygenase
–
biphenyl + NADPH + O2 <=> cis-2,3-dihydro-2,3-dihydroxybiphenyl + NADP+ 1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
3-methylbenzaldehyde + NADP+ + H2O <=> 3-methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
–
–
1-naphthalene_methanol + NAD+ <=> 1-naphthaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
–
2,6-dibromo-p-hydroquinone <=> 2-bromomaleylacetate not assigned
 –
methane + NADH + O2 + H+ <=> methanol + NAD+ + H2O 1.14.13.230 butane monooxygenase (soluble)
1.14.13.25 methane monooxygenase (soluble)
1.14.18.3 methane monooxygenase (particulate)
–
–
–
NAD+ + 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate <=> CO2 + NADH + 3-methylcatechol 1.3.1.68 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
–
(3R)-3-isopropenyl-6-oxoheptanoate + CoA + ATP <=> (3R)-3-Isopropenyl-6-oxoheptanoyl-CoA + ADP + phosphate 6.2.1
–
Naphthyl-2-methylene-succinyl-CoA + H2O <=> Naphthyl-2-hydroxymethyl-succinyl_CoA 4.2.1
–
(R)-2-benzylsuccinyl-CoA + flavin <=> (E)-2-benzylidenesuccinyl-CoA + reduced_flavodoxin 1.3.8.3 (R)-benzylsuccinyl-CoA dehydrogenase
–
NAD+ + cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate <=> CO2 + NADH + 4-methylcatechol 1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
–
4-hydroxybenzoate + NADPH + O2 + H+ <=> 3,4-dihydroxybenzoate + NADP+ + H2O 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
–
–
2-Hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA + acceptor <=> 4-Isopropenyl-2-oxy-cyclohexanecarboxyl-CoA + reduced_acceptor 1.1
–
acetaldehyde + CoA + NAD+ <=> acetyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.42 hexadecanal dehydrogenase (acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)
–
–
–
–
3-methyl-cis,cis-muconate <=> 4-Carboxymethyl-3-methylbut-2-en-1,4-olide 5.5.1.1 muconate cycloisomerase
–
2-hydroxy-3-methylbenzaldehyde + NAD+ + H2O <=> 3-methylsalicylate + NADH + H+ 1.2.1
–
H+ + salicylate + O2 + NADH <=> catechol + CO2 + H2O + NAD+ 1.14.13.1 salicylate 1-monooxygenase
–
(3R)-6-Hydroxy-3-isopropenyl-heptanoate <=> (3R)-3-isopropenyl-6-oxoheptanoate not assigned
 –
benzoylpropionyl-CoA + CoA <=> benzoyl-CoA + acetyl-CoA 2.3.1
2.3.1.16 acetyl-CoA C-acyltransferase
–
–
6-oxohexanoate + H2O + NADP+ <=> H+ + adipate + NADPH 1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.63 6-oxohexanoate dehydrogenase
–
–
2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate <=> 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + CO2 4.1.1
–
2-hydroxy-6-oxoocta-2,4-dienoate + H2O <=> 2-hydroxy-2,4-pentadienoate + propionate 3.7.1
–
4-chlorobiphenyl + O2 + NADPH + H+ <=> cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NADP+ 1.14.12.18 biphenyl 2,3-dioxygenase
–
1,4-dichlorobenzene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-3,6-dichlorocyclohexa-3,5-diene + NAD+ 1.14.12.26 chlorobenzene dioxygenase
–
trans-cinnamate + reduced_flavodoxin + O2 <=> p-coumaric_acid + flavin + H2O 1.14.14.91 trans-cinnamate 4-monooxygenase
–
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ <=> H+ + 3-(2,3-dihydroxyphenyl)propanoate + NADH 1.3.1.87 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
–
2,3-Dihydroxy-p-cumate + O2 <=> 2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate + H+ 1.13.11
1.13.11.M5
–
–
m-cresol + O2 + NADH + H+ <=> 3-Hydroxybenzyl_alcohol + NAD+ + H2O 1.14.13
–
cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NAD+ <=> 2,3-Dihydroxy-4''-chlorobiphenyl + NADH + H+ 1.3.1.56 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
–
cuminaldehyde + NAD+ + H2O <=> H+ + cumic_acid + NADH 1.2.1.29 aryl-aldehyde dehydrogenase
–
4-coumaroyl-CoA <=> caffeoyl-CoA 1.14.13
–
2,6-dichlorohydroquinone + O2 + H2O <=> H+ + 2-chloromaleylacetate + Cl- 1.13.11
1.13.11.66 hydroquinone 1,2-dioxygenase
–
–
trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylic_acid + NAD+ <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ 1.3.1.87 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
–
3-Hydroxybenzaldehyde + NAD+ + H2O <=> 3-hydroxybenzoate + NADH + H+ 1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.67 vanillin dehydrogenase
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
–
–
–
–
–
–
–
–
2-bromomaleylacetate + NADH <=> maleylacetate + NAD+ + Br- 1.3.1.32 maleylacetate reductase
–
2,4-Dichlorotoluene + NADH + O2 + H+ <=> 4,6-Dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ 1.14.12
–
Styrene + O2 + NADH + H+ <=> Styrene-cis-2,3-dihydrodiol + NAD+ 1.14.12
–
CoA + 4-hydroxybenzoate + ATP <=> 4-hydroxybenzoyl-CoA + diphosphate + AMP 6.2.1.27 4-hydroxybenzoate---CoA ligase
–
ethylbenzene + O2 + NADH + H+ <=> cis-1,2-dihydro-3-ethylcatechol + NAD+ 1.14.12
–
NAD+ + cis-1,2-dihydro-3-ethylcatechol <=> H+ + NADH + 3-ethylcatechol 1.3.1.66 cis-dihydroethylcatechol dehydrogenase
–
3-vinylcatechol + O2 <=> 2-Hydroxy-6-oxoocta-2,4,7-trienoate 1.13.11.2 catechol 2,3-dioxygenase
–
2,4-dinitrotoluene + O2 + NADH <=> 4-methyl-5-nitrocatechol + NAD+ + nitrite 1.14.12.24 2,4-dinitrotoluene dioxygenase
–
benzyl_alcohol + NAD+ <=> benzaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.245 cyclohexanol dehydrogenase
1.1.1.265 3-methylbutanal reductase
1.1.1.307 D-xylose reductase
1.1.1.347 geraniol dehydrogenase (NAD+)
1.1.1.6 glycerol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.73 octanol dehydrogenase
1.1.1.90 aryl-alcohol dehydrogenase
1.14.14.51 (S)-limonene 6-monooxygenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
–
–
–
–
–
–
–
–
–
–
–
–
–
Toluene + O2 + NADH + H+ <=> (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol + NAD+ 1.14.12.11 toluene dioxygenase
–
3-ethylcatechol + O2 <=> 2-hydroxy-6-oxoocta-2,4-dienoate 1.13.11
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
–
–
2-chloromaleylacetate + NADH <=> maleylacetate + Cl- + NAD+ 1.3.1.32 maleylacetate reductase
–
4-Isopropenyl-2-oxy-cyclohexanecarboxyl-CoA + H2O <=> 3-Isopropenylpimelyl-CoA 3.7.1
–
(4S)-(+)-muconolactone <=> 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid 5.3.3.4 muconolactone Delta-isomerase
–
fluorobenzene + NADH + O2 + H+ <=> 4-Fluorocyclohexadiene-cis,cis-1,2-diol + NAD+ 1.14.12
–
1-methylnaphthalene + O2 + NADH + H+ <=> 1-naphthalene_methanol + NAD+ + H2O 1.14.13
–
2-hydroxy-2H-chromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate 2.5.1.18 glutathione transferase
5.99.1.4 2-hydroxychromene-2-carboxylate isomerase
–
–
cinnamoyl-CoA + reduced_flavodoxin + O2 <=> 4-coumaroyl-CoA + flavin + H2O 1.14.14.91 trans-cinnamate 4-monooxygenase
–
H+ + 4-hydroxybenzoate <=> CO2 + phenol 4.1.1.103 gamma-resorcylate decarboxylase
4.1.1.61 4-hydroxybenzoate decarboxylase
–
–
(R)-2-benzylsuccinate <=> Toluene + fumarate 4.1.99.11 benzylsuccinate synthase
–
2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde + H2O <=> formate + (2E,4Z)-2-hydroxyhexa-2,4-dienoate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase
–
acetophenone + HCO3- + ATP + H2O <=> H+ + 3-oxo-3-phenylpropionic_acid + ADP + phosphate 6.4.1.8 acetophenone carboxylase
–
2-Hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate + H2O <=> 2-hydroxy-2,4-hexadienedioate + catechol + H+ 3.7.1
–
cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized_ferredoxin + ADP + phosphate <=> benzoyl-CoA + reduced_ferredoxin_[iron-sulfur]_cluster + ATP + H2O 1.3.7.8 benzoyl-CoA reductase
–
H+ + O2 + NADH + Benzene <=> NAD+ + cis-benzene_dihydrodiol 1.14.12.11 toluene dioxygenase
1.14.12.3 benzene 1,2-dioxygenase
–
–
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ <=> 4,5-Dihydroxyphthalate + NADH + H+ 1.3.1.64 phthalate 4,5-cis-dihydrodiol dehydrogenase
–
2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate 3.7.1
3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
–
–
1-naphthaldehyde + NAD+ + H2O <=> 1-naphthoic_acid + NADH 1.2.1
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.65 salicylaldehyde dehydrogenase
–
–
–
–
1,1-Dichloro-2-(dihydroxy-4''-chlorophenyl)-2-(4''-chlorophenyl)ethylene + O2 <=> 6-Oxo-2-hydroxy-7-(4''-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate 1.13.11
–
2,2',3-trihydroxybiphenyl_ether + O2 <=> 2-Hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate + H+ 1.13.11
–
(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ <=> 3,4-dihydroxybenzoate + CO2 + NADH 1.3.1.53 (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
–
5-carboxymethyl-2-hydroxymuconate_semialdehyde + NAD+ + H2O <=> H+ + 5-Carboxymethyl-2-hydroxymuconate + NADH 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
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4-Fluorobenzoate + NADH + H+ + O2 <=> 4-fluoro-2-hydro-1,2-dihydroxybenzoate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
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4-(hydroxymethyl)benzenesulfonate + NAD+ <=> 4-formylbenzenesulfonate + H+ + NADH 1.1.1.257 4-(hydroxymethyl)benzenesulfonate dehydrogenase
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4-Carboxymethyl-3-methylbut-2-en-1,4-olide <=> 4-methyl-3-oxoadipate_enol-lactone 5.3.3
5.3.3.4 muconolactone Delta-isomerase
5.4.99.14 4-carboxymethyl-4-methylbutenolide mutase
5.5.1
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n-butane + NADH + O2 + H+ <=> 1-butanol + NAD+ + H2O 1.14.13.230 butane monooxygenase (soluble)
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Salicylaldehyde + NAD+ + H2O <=> salicylate + NADH + H+ 1.2.1
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
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p-xylene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 4-methylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase
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3-methylbenzoate + NADH + O2 + H+ <=> 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ 1.14.12
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4-methylcatechol + O2 <=> 2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde 1.13.11.2 catechol 2,3-dioxygenase
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3,4-Dihydroxyphenanthrene + O2 <=> 2-Hydroxy-2H-benzo[h]chromene-2-carboxylate 1.13.11
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cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+ <=> 2,3-Dihydroxybiphenyl + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
1.3.1.56 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
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2-hydroxymuconate-6-semialdehyde + H2O <=> formate + 2-oxopent-4-enoate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase
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succinyl-CoA + (R)-2-benzylsuccinate <=> succinate + (R)-2-benzylsuccinyl-CoA 2.8.3.15 succinyl-CoA:(R)-benzylsuccinate CoA-transferase
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Cinnamic_acid + NADH + O2 + H+ <=> trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylic_acid + NAD+ 1.14.12.19 3-phenylpropanoate dioxygenase
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1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + NADH + H+ + O2 <=> cis-3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorocyclohexa-3,5-diene-1,2-diol + NAD+ 1.14.12
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4-hydroxy-2-oxopentanoate <=> 2-oxopent-4-enoate + H2O 4.2.1.80 2-oxopent-4-enoate hydratase
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2-naphthalenemethanol + NAD+ <=> 2-naphthaldehyde + NADH 1.1.1.1 alcohol dehydrogenase
1.1.1.90 aryl-alcohol dehydrogenase
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1,2,3,4-tetrachlorobenzene + O2 + NADPH + H+ <=> cis-Chlorobenzene_dihydrodiol + NADP+ 1.14.12
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Phthalate_3,4-cis-dihydrodiol + NAD+ <=> 3,4-dihydroxyphthalate + NADH + H+ 1.3.1
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Visualization of the pathway